Anti-CDCA7L抗体 YB--5963R报价/价格-抗体 Anti-CDCA7L抗体 Ybsc

生物论坛 抗体

 Anti-CDCA7L抗体

产品编号 YB-5963R 英文名称 CDCA7L 中文名称 细胞分裂周期相关蛋白JPO2抗体 别    名 c Myc Interacting protein JPO2; DKFZp762L0311; RAM2; HR1; JPO2; Protein JPO2; R1 antibody Transcription Factor RAM2.CDA7L_HUMAN   规格价格 100ul/1580元 购买    200ul/2480元 购买    大包装/询价 说 明 书 100ul  200ul 研究领域 肿瘤  细胞生物  免疫学  信号转导  细胞周期蛋白   抗体来源 Rabbit 克隆类型 Polyclonal 交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,  产品应用 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 (石蜡切片需做抗原修复)  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分 子 量 49kDa 细胞定位 细胞核 细胞浆  性    状 Lyophilized or Liquid 浓    度 1mg/ml 免 疫 原 KLH conjugated synthetic peptide derived from human CDCA7L:381-454/454  亚    型 IgG 纯化方法 affinity purified by Protein A 储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. PubMed PubMed 产品介绍 background: CDCA7L is a member of the CDCA (cell division cycle associated) protein family. Members of this family have expression patterns associated with other known cell cycle genes such as cyclins and CDC genes. CDCA7L plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. It also plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. It is involved in apoptotic signaling pathways and may act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1. Function: Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1. Subunit: Interacts with MYC and PSIP1. Subcellular Location: Cytoplasm. Nucleus. Note=Associates with chromatin. Translocates from cytoplasm to nucleus under *** induction. Tissue Specificity: Ubiquitous. Overexpressed in medulloblastoma. SWISS: Q96GN5 Gene ID: 55536 Database links:

Entrez Gene: 55536 Human

Omim: 609685 Human

SwissProt: Q96GN5 Human

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application

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