Anti-TUSC2抗体 YB--5707R报价/价格-抗体 Anti-TUSC2抗体 Ybscie

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 Anti-TUSC2抗体

产品编号 YB-5707R 英文名称 TUSC2 中文名称 血小板源性生长因子A相关蛋白2抗体 别    名 C3orf11; FUS1; Fusion 1 protein; PAP; PDAP2; PDGFA associated protein 2; Tumor suppressor candidate 2; TUSC 2; TUSC2_HUMAN.   规格价格 100ul/1580元 购买    200ul/2480元 购买    大包装/询价 说 明 书 100ul  200ul 研究领域 肿瘤  免疫学  染色质和核信号  信号转导  生长因子和***  转录调节因子   抗体来源 Rabbit 克隆类型 Polyclonal 交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,  产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 (石蜡切片需做抗原修复)  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分 子 量 12kDa 性    状 Lyophilized or Liquid 浓    度 1mg/ml 免 疫 原 KLH conjugated synthetic peptide derived from human TUSC2:31-100/110  亚    型 IgG 纯化方法 affinity purified by Protein A 储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. PubMed PubMed 产品介绍 background: TUSC2/FUS1 is a novel tumor suppressor gene identified in the human chromosome 3p21.3 region where allele losses and genetic alterations occur early and frequently for many human cancers. Expression of TUSC2 protein is absent or reduced in the majority of lung cancers and premalignant lung lesions. Restoration of TUSC2 function in 3p21.3-deficient non-small cell lung carcinoma cells significantly inhibits tumor cell growth by induction of apoptosis and alteration of cell cycle kinetics. TUSC2 may induce apoptosis through the activation of the intrinsic mitochondrial-dependent and Apaf-1-associated pathways and inhibit the function of protein tyrosine kinases including EGFR, PDGFR, AKT, c-Abl, and c-Kit. Function: May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells.  Tissue Specificity: Strong expression in heart, lung, skeletal muscle, kidney, and pancreas, followed by brain and liver, lowest levels in placenta.  Post-translational modifications: Myristoylation is required for tumor suppressor activity. Similarity: Belongs to the TUSC2 family.  SWISS: O75896 Gene ID: 11334 Database links:

Entrez Gene: 11334 Human

Entrez Gene: 80385 Mouse

Entrez Gene: 448842 Pig

Entrez Gene: 501052 Rat

Omim: 607052 Human

SwissProt: O75896 Human

SwissProt: Q9WVF8 Mouse

Unigene: 517981 Human

Unigene: 21739 Mouse

Unigene: 120731 Rat

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

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