Anti-PKA regulatory subunit I beta抗体 YB--3965R报价/价格-抗

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 Anti-PKA regulatory subunit I beta抗体

产品编号 YB-3965R 英文名称 PKA regulatory subunit I beta 中文名称 蛋白激酶受体相关1β抗体 别    名 cAMP dependent protein kinase type I beta regulatory subunit; PKARI beta; PRKAR 1; PRKAR 1B; PRKAR1; PRKAR1B; PRKAR1B protein; Protein kinase cAMP dependent regulatory type I beta; RI beta; KAPCB_HUMAN.   规格价格 100ul/1380元 购买    200ul/2200元 购买    大包装/询价 说 明 书 100ul  200ul 研究领域 肿瘤  细胞生物  免疫学  信号转导  转录调节因子  激酶和***酸酶   抗体来源 Rabbit 克隆类型 Polyclonal 交叉反应 Human, Mouse, Rat,  产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 (石蜡切片需做抗原修复)  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分 子 量 40kDa 细胞定位 细胞核 细胞浆 细胞膜  性    状 Lyophilized or Liquid 浓    度 1mg/ml 免 疫 原 KLH conjugated synthetic peptide derived from human PKA regulatory subunit I beta:5-100/351  亚    型 IgG 纯化方法 affinity purified by Protein A 储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. PubMed PubMed 产品介绍 background: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Several alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jun 2011]. Function: Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible. Subunit: Belongs to the cAMP-dependent kinase regulatory chain family. Contains 2 cyclic nucleotide-binding domains. Subcellular Location: Cytoplasm. Cell membrane. Nucleus. Note=Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the cytoplasm. Tissue Specificity: Isoform 1 is most abundant in the brain, with low level expression in kidney. Isoform 2 is predominantly expressed in thymus, spleen and kidney. Isoform 3 and isoform 4 are only expressed in the brain. Post-translational modifications: Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively (By similarity).  Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.  Contains 1 AGC-kinase C-terminal domain.  Contains 1 protein kinase domain. SWISS: P22694 Gene ID: 5567 Database links: UniProtKB/Swiss-Prot: P22694.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications