Anti-STXBP1/Munc18-1抗体 YB--3954R报价/价格-抗体 Anti-STXBP1

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 Anti-STXBP1/Munc18-1抗体

产品编号 YB-3954R 英文名称 STXBP1/Munc18-1 中文名称 神经突触前膜胞内蛋白18抗体 别    名 Munc 18 1; Munc 18a; NSec1; p67; Rb sec1; STXBP1; Syntaxin binding protein 1; Unc 18 homolog; Unc 18A; Unc18 1; STXB1_HUMAN; Syntaxin-binding protein 1; MUNC18-1; N-Sec1; Protein unc-18 homolog 1; Unc18-1; Protein unc-18 homolog A; Unc-18A; p67.   规格价格 100ul/1380元 购买    200ul/2200元 购买    大包装/询价 说 明 书 100ul  200ul 研究领域 肿瘤  细胞生物  免疫学  神经生物学   抗体来源 Rabbit 克隆类型 Polyclonal 交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Horse,  产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 (石蜡切片需做抗原修复)  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分 子 量 68kDa 细胞定位 细胞浆 细胞膜  性    状 Lyophilized or Liquid 浓    度 1mg/ml 免 疫 原 KLH conjugated synthetic peptide derived from human Munc18:11-110/594  亚    型 IgG 纯化方法 affinity purified by Protein A 储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. PubMed PubMed 产品介绍 background: This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010] Function: May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions. Subunit: Binds SYTL4. Interacts with STX1A. Subcellular Location: Cytoplasm. Membrane; Peripheral membrane protein. Tissue Specificity: Brain and spinal cord. Highly enriched in axons. DISEASE: Defects in STXBP1 are the cause of epileptic encephalopathy early infantile type 4 (EIEE4) [MIM:612164]. Affected individuals have neonatal or infantile onset of seizures, suppression-burst pattern on EEG, profound mental retardation, and MRI evidence of hypomyelination. Similarity: Belongs to the STXBP/unc-18/SEC1 family. SWISS: P61764  Gene ID: 6812 Database links:

Entrez Gene: 6812 Human

Entrez Gene: 20910 Mouse

Entrez Gene: 25558 Rat

Entrez Gene: 404293 Chicken

Omim: 602926 Human

SwissProt: Q6R748 Chicken

SwissProt: P61764 Human

SwissProt: O08599 Mouse

SwissProt: P61765 Rat

Unigene: 288229 Human

Unigene: 278865 Mouse

Unigene: 80843 Rat

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

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