Anti-Plexin A2抗体 YB--3638R报价/价格-抗体 Anti-Plexin A2抗

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 Anti-Plexin A2抗体

产品编号 YB-3638R 英文名称 Plexin A2 中文名称 神经丛蛋白A2抗体 别    名 PlexinA2; PLXA2; PLXNA2; Semaphorin receptor OCT.   规格价格 100ul/1380元 购买    200ul/2200元 购买    大包装/询价 说 明 书 100ul  200ul 研究领域 免疫学  神经生物学  细胞膜受体  细胞表面分子   抗体来源 Rabbit 克隆类型 Polyclonal 交叉反应 Human, Mouse, Rat,  产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分 子 量 205kDa 细胞定位 细胞膜  性    状 Lyophilized or Liquid 浓    度 1mg/ml 免 疫 原 KLH conjugated synthetic peptide derived from human Plexin A2:1251-1400/1894 <Extracellular> 亚    型 IgG 纯化方法 affinity purified by Protein A 储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. PubMed PubMed 产品介绍 background: Plexin A2 is a coreceptor for SEMA3A and is necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. This coreceptor plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin in which the plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Function: Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity). Subunit: Homodimer. The PLXNA2 homodimer interacts with a SEMA6A homodimer, giving rise to a heterotetramer. Interacts directly with NRP1 and NRP2 (By similarity). Interacts with RND1. Subcellular Location: Cell membrane; Single-pass type I membrane protein (By similarity). Tissue Specificity: Detected in fetal brain. Similarity: Belongs to the plexin family. Contains 4 IPT/TIG domains. Contains 1 Sema domain.  SWISS: O75051 Gene ID: 5362 Database links:

Entrez Gene: 5362 Human

Entrez Gene: 18845 Mouse

Entrez Gene: 289392 Rat

Omim: 601054 Human

SwissProt: O75051 Human

SwissProt: P70207 Mouse

Unigene: 497626 Human

Unigene: 2251 Mouse

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.  Plexin A2蛋白是SEMA3A的辅助受体,Plexin A2蛋白在神经细胞轴突导向, 生长和细胞迁移中发挥作用

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