Anti-HRH3抗体 YB--3635R报价/价格-抗体 Anti-HRH3抗体 Ybscienc

生物论坛 抗体

 Anti-HRH3抗体

产品编号 YB-3635R 英文名称 HRH3 中文名称 组织胺H3受体抗体 别    名 G protein coupled receptor 97; GPCR 97; GPCR97; H3R; HH 3R; HH3 R; HH3R; Histamine H3 receptor; Histamine receptor H3; HRH 3; HRH3; HRH-3.  
Specific References  (1)     |     bs-3635R has been referenced in 1 publications.
[IF=1.54] Møller, M. Nue, et al. "Expression of histamine receptors in the human endolymphatic sac: the molecular rationale for betahistine use in Menieres disease." European Archives of Oto-Rhino-Laryngology: 1-6.  IHC-P ;  Human.  
PubMed:26208913
 
规格价格 100ul/1380元 购买    200ul/2200元 购买    大包装/询价 说 明 书 100ul  200ul 研究领域 肿瘤  细胞生物  免疫学  信号转导  转录调节因子   抗体来源 Rabbit 克隆类型 Polyclonal 交叉反应 Human, Mouse, Rat, Dog, Cow, Horse,  产品应用 IHC-P=1:400-800 IHC-F=1:400-800 (石蜡切片需做抗原修复)  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分 子 量 49kDa 细胞定位 细胞膜  性    状 Lyophilized or Liquid 浓    度 1mg/ml 免 疫 原 KLH conjugated synthetic peptide derived from human HRH3/GPCR97:121-220/445  亚    型 IgG 纯化方法 affinity purified by Protein A 储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. PubMed PubMed 产品介绍 background: Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene encodes one of the histamine receptors (H3) which belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and can regulate neurotransmitter release. This receptor can also increase voltage-dependent calcium current in smooth muscles and innervates the blood vessels and the heart in cardiovascular system. [provided by RefSeq, Jul 2008]. Function: The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Expressed predominantly in the CNS, with the greatest expression in the thalamus and caudate nucleus. The various isoforms are mainly coexpressed in brain, but their relative expression level varies in a region-specific manner. Isoform 3 and isoform 7 are highly expressed in the thalamus, caudate nucleus and cerebellum while isoform 5 and isoform 6 show a poor expression. Isoform 5 and isoform 6 show a high expression in the amygdala, substantia nigra, cerebral cortex and hypothalamus. Isoform 7 is not found in hypothalamus or substantia nigra. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: Q9Y5N1 Gene ID: 11255 Database links:

Entrez Gene: 11255 Human

Entrez Gene: 99296 Mouse

Entrez Gene: 85268 Rat

Omim: 604525 Human

SwissProt: Q9Y5N1 Human

SwissProt: P58406 Mouse

SwissProt: Q9QYN8 Rat

Unigene: 251399 Human

Unigene: 285360 Mouse

Unigene: 7617 Rat

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

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