Anti-SWAP70抗体 YB--8630R报价/价格-抗体 Anti-SWAP70抗体 Ybsc

生物论坛 抗体


产品编号 YB-8630R 英文名称 SWAP70 中文名称 开关相关蛋白70抗体 别    名 KIAA0640; 70kDa; AV235546; FLJ39540; HSPC321; SWA 70 protein; SWAP 70; SWAP switching B-cell complex 70kDa subunit; SWAP-70; SWAP70; Switch associated protein 70; Switch-associated protein 70; SWP70_HUMAN.   规格价格 100ul/1380元 购买    200ul/2200元 购买    大包装/询价 说 明 书 100ul  200ul 研究领域 细胞生物  免疫学  信号转导   抗体来源 Rabbit 克隆类型 Polyclonal 交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,  产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分 子 量 69kDa 细胞定位 细胞浆 细胞膜  性    状 Lyophilized or Liquid 浓    度 1mg/ml 免 疫 原 KLH conjugated synthetic peptide derived from human SWAP70:131-230/585  亚    型 IgG 纯化方法 affinity purified by Protein A 储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. PubMed PubMed 产品介绍 Function: Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion. Subcellular Location: Cytoplasm. Cell membrane. Nucleus. Cell projection > lamellipodium. In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus. In activated, class-switching B-cells it is associated with membrane IgG but not IgM. Localized to loose actin filament arrays located behind actively extending lamellipodia. Tissue Specificity: Expressed only in mature B-cells including those associated with mucosa-associated tissue and bronchus-associated tissue (PubMed:10681448). Widely expressed. Abundant in spleen, and fairly abundant in kidney, lung and liver. Also found in monocytes and macrophages (PubMed:12925760). Post-translational modifications: Tyrosine-phosphorylated. Similarity: Contains 1 PH domain. SWISS: Q9UH65 Gene ID: 23075 Database links:

Entrez Gene: 23075 Human

Entrez Gene: 20947 Mouse

Entrez Gene: 293410 Rat

Omim: 604762 Human

SwissProt: Q5F4B2 Chicken

SwissProt: P0C1G6 Cow

SwissProt: Q9UH65 Human

SwissProt: Q6A028 Mouse

Unigene: 153026 Human

Unigene: 334144 Mouse

Unigene: 92644 Rat

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    产品图片
Sample: U937 Cell (Human) Lysate at 40 ug Primary: Anti-SWAP70(bs-8630R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 69kD Observed band size: 63kD