Anti-phospho-SPHK2 (Thr614)抗体 YB--17661R报价/价格-抗体 Ant

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 Anti-phospho-SPHK2 (Thr614)抗体

产品编号 YB-17661R 英文名称 phospho-SPHK2 (Thr614) 中文名称 ***酸化鞘氨醇激酶2抗体 别    名 SPHK2 (phospho T614); p-SPHK2 (phospho T614); SK 2; Sphingosine kinase 2; Sphingosine kinase type 2; SPHK2; SPHK2_HUMAN; SPK 2.   规格价格 100ul/1580元 购买        大包装/询价 说 明 书 100ul   产品类型 ***酸化抗体  研究领域 肿瘤  细胞生物  神经生物学  信号转导  激酶和***酸酶  G蛋白信号   抗体来源 Rabbit 克隆类型 Polyclonal 交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,  产品应用 WB=1:500-2000 ELISA=1:500-1000   not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分 子 量 72kDa 细胞定位 细胞浆 细胞膜  性    状 Lyophilized or Liquid 浓    度 1mg/ml 免 疫 原 KLH conjugated synthesised phosphopeptide derived from human SPHK2 around the phosphorylation site of Thr614:PL(p-T)PR  亚    型 IgG 纯化方法 affinity purified by Protein A 储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. PubMed PubMed 产品介绍 background: This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011] Function: Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra-and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides. Subcellular Location: Cytoplasm. Membrane and Lysosome membrane. Similarity: Contains 1 DAGKc domain. SWISS: Q9NRA0 Gene ID: 56848 Database links:

Entrez Gene: 56848 Human

Entrez Gene: 56632 Mouse

Entrez Gene: 308589 Rat

Omim: 607092 Human

SwissProt: Q9NRA0 Human

SwissProt: Q9JIA7 Mouse

Unigene: 528006 Human

Unigene: 24222 Mouse

Unigene: 41053 Rat

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    产品图片
Sample:  Cerebrum (Mouse) Lysate at 40 ug Siha(huamn) Cell Lysate at 40 ug Primary: Anti-p-SPHK2(Thr614) (bs-17661R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 72 kD Observed band size: 75 kD